![]() ![]() Hypercapnia in critically ill patients is related to readmission to the intensive care unit and increased in-hospital and 30-day mortality. ![]() Hypercatabolic states, sepsis, thyrotoxicosis, overfeeding, and malignant hyperthermia can elevate CO 2 levels each degree Celsius increase in body temperature increases CO 2 production by 14%. Ĭarbon dioxide levels alter in response to alveolar ventilation (VA) changes caused by respiratory depression, airway obstruction, and increased dead space (VD), reflecting excessive production of CO 2, inadequate elimination of the same, or a neuromuscular disorder. Hypercapnia is the elevation in the partial pressure of carbon dioxide (PaCO 2) above 45 mmHg. Healthy people can regulate CO 2 levels by negative feedback mechanisms modulated by central and peripheral chemoreceptors. Carbon dioxide (CO 2) is a gas and metabolic product that influences several cellular processes, including respiration, the affinity of hemoglobin for oxygen, and regulation of blood pH and acid-based balance.
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